OUR PAPERS

An immune-based tool platform for in vivo cell clearance.

Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL

Life Science Alliance (2023). doi: 10.26508/lsa.202201869.

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Rethinking cancer targeting strategies in the era of smart cell therapeutics.

Greg M. Allen, Wendell A. Lim

Nature Reviews Cancer (2022). doi: 10.1038/s41568-022-00505-x.

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Synthetic cytokine circuits that drive T cells into immune-excluded tumors.

Greg M. Allen, Nick W. Frankel, Nish R. Reddy, Hersh K. Bhargava, Maia A. Yoshida, Sierra R. Stark, Megan Purl, Jungmin Lee, Jacqueline L. Yee, Wei Yu, Aileen W. Li, K. Christopher Garcia, Hana El-Samad, Kole T. Roybal, Matthew H. Spitzer, Wendell A. Lim

Science (2022). doi: 10.1126/science.aba1624.

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Media & Press

• Cell Design Institute Explanatory Video (YouTube)
• Killing Pancreatic Cancer with T Cells that Supercharge Themselves (UCSF News)
• Perspective: Engineering time-controlled immunotherapy (Science)
• Cancer treatments boosted by immune-cell hacking (Nature News)

Precise T cell recognition programs designed by transcriptionally linking multiple receptors.

Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA

Science (2020). doi: 10.1126/science.abc6270.

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Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies.

Ruth Dannenfelser, Gregory M Allen, Benjamin VanderSluis, Ashley K Koegel, Sarah Levinson, Sierra R Stark, Vicky Yao, Alicja Tadych, Olga G Troyanskaya, Wendell A Lim

Cell systems (2020). doi: 10.1016/j.cels.2020.08.002.

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Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration.

Allen GM, Lee KC, Barnhart EL, Tsuchida MA, Wilson CA, Gutierrez E, Groisman A, Theriot JA, Mogilner A

Cell Systems (2020). doi: 10.1016/j.cels.2020.08.008.

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Balance between cell-substrate adhesion and myosin contraction determines the frequency of motility initiation in fish keratocytes.

Barnhart E, Lee KC, Allen GM, Theriot JA, Mogilner A

Proc Natl Acad Sci U S A (2015). doi: 10.1073/pnas.1417257112.

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Electrophoresis of cellular membrane components creates the directional cue guiding keratocyte galvanotaxis.

Allen GM, Mogilner A, Theriot JA

Current Biology (2013). doi: 10.1016/j.cub.2013.02.047.

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Myosin II contributes to cell-scale actin network treadmilling through network disassembly.

Wilson CA, Tsuchida MA, Allen GM, Barnhart EL, Applegate KT, Yam PT, Ji L, Keren K, Danuser G, Theriot JA

Nature (2010). doi: 10.1038/nature08994.

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Bipedal locomotion in crawling cells.

Barnhart EL, Allen GM, Jülicher F, Theriot JA

Biophysical Journal (2010). doi: 10.1016/j.bpj.2009.10.058.

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Mechanism of shape determination in motile cells.

Keren K, Pincus Z, Allen GM, Barnhart EL, Marriott G, Mogilner A, Theriot JA

Nature (2008). doi: 10.1038/nature06952.

Journal Website | PubMed