OUR PAPERS

An immune-based tool platform for in vivo cell clearance.

Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL

Life Science Alliance (2023). doi: 10.26508/lsa.202201869.

Journal Website | PubMed

Rethinking cancer targeting strategies in the era of smart cell therapeutics.

Greg M. Allen, Wendell A. Lim

Nature Reviews Cancer (2022). doi: 10.1038/s41568-022-00505-x.

Access: PDF | Journal Website | PubMed

Synthetic cytokine circuits that drive T cells into immune-excluded tumors.

Greg M. Allen, Nick W. Frankel, Nish R. Reddy, Hersh K. Bhargava, Maia A. Yoshida, Sierra R. Stark, Megan Purl, Jungmin Lee, Jacqueline L. Yee, Wei Yu, Aileen W. Li, K. Christopher Garcia, Hana El-Samad, Kole T. Roybal, Matthew H. Spitzer, Wendell A. Lim

Science (2022). doi: 10.1126/science.aba1624.

Access: PDF | Journal Website | PubMed

Media & Press

• Cell Design Institute Explanatory Video (YouTube)
• Killing Pancreatic Cancer with T Cells that Supercharge Themselves (UCSF News)
• Perspective: Engineering time-controlled immunotherapy (Science)
• Cancer treatments boosted by immune-cell hacking (Nature News)

Precise T cell recognition programs designed by transcriptionally linking multiple receptors.

Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA

Science (2020). doi: 10.1126/science.abc6270.

Journal Website | PubMed

Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration.

Allen GM, Lee KC, Barnhart EL, Tsuchida MA, Wilson CA, Gutierrez E, Groisman A, Theriot JA, Mogilner A

Cell Systems (2020). doi: 10.1016/j.cels.2020.08.008.

Journal Website | PubMed

Balance between cell-substrate adhesion and myosin contraction determines the frequency of motility initiation in fish keratocytes.

Barnhart E, Lee KC, Allen GM, Theriot JA, Mogilner A

Proc Natl Acad Sci U S A (2015). doi: 10.1073/pnas.1417257112.

Journal Website | PubMed

Electrophoresis of cellular membrane components creates the directional cue guiding keratocyte galvanotaxis.

Allen GM, Mogilner A, Theriot JA

Current Biology (2013). doi: 10.1016/j.cub.2013.02.047.

Journal Website | PubMed

Myosin II contributes to cell-scale actin network treadmilling through network disassembly.

Wilson CA, Tsuchida MA, Allen GM, Barnhart EL, Applegate KT, Yam PT, Ji L, Keren K, Danuser G, Theriot JA

Nature (2010). doi: 10.1038/nature08994.

Journal Website | PubMed

Bipedal locomotion in crawling cells.

Barnhart EL, Allen GM, Jülicher F, Theriot JA

Biophysical Journal (2010). doi: 10.1016/j.bpj.2009.10.058.

Journal Website | PubMed

Mechanism of shape determination in motile cells.

Keren K, Pincus Z, Allen GM, Barnhart EL, Marriott G, Mogilner A, Theriot JA

Nature (2008). doi: 10.1038/nature06952.

Journal Website | PubMed